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Gotu Kola Extract

trade name

part used

ingredient

specification

tests methd

gotu cola

all plant

asiaticoside

40%

HPLC

Latin name: Centella Asiatica
Botanical Source: Centella Asiatica ( L. ) Urban.
Specification:
1) Active ingredient: Asiaticoside&Madecassoside, 10%-90% HPLC
Appearance: From Dark yellow powder to Milk white powder
2) Active ingredient: Asiaticoside, 10%-90% HPLC
Appearance: From Lightless yellow powder to White powder
3) Active ingredient: Madicassoside, 10%-95% HPLC
Appearance: From yellow powder to White powder
4) Active ingredient: Madecassic acid, 10%-95% HPLC
Appearance: From yellow powder to White powder
5) Active ingredient: Asiatic Acid, 95% HPLC
Appearance: white to creamy powder
6) Active ingredient: Selected Triterpenes (Asiaticoside, 34-44% Madicassic acid & Asiatic acid 54-66%) HPLC
Appearance: White powder
7) Active ingredient: Triterpenic Genine (Madecassic acid & Asiatic acid), 50%-95% HPLC.
Appearance: White powder

Function:
Pharmacological action
Helps prevent Varicose Veins/Hemorrhoids :The circulatory improvement occurs because gotu kola decreases vein hardening, improves the connective tissue around veins, and helps the blood to flow throug Overcoming stress and fatigue: Gotu kola contains contains sedative and an abundance of "anti-stress" B vitamins, this kind of vitamins can be effect in relaxing body. It can be used as a nervine and general tonic. Wound-healing and scars: Research showed that a Gotu kola extract enriched with asiaticoside stimulated the synthesis of collagen by fibroblasts in vitro and it helps reduce the redness and thickness of scars by causing them to mature faster. 
 So Gotu kola extract can be used for wound healing purpose and removal of scars in the skin .
Leprosy : Research has shown that asiaticoside may provide treatment for leprosy.Leprosy-causing bacteria are coated in a wax-like substance that the immune system can't penetrate. However, gota kola dissolves the waxy coating, allowing the immune system to destroy the bacteria.
Mental disorder: Alcoholic extract prolonged the hypnotic effect of Sodium phenobarbitone in mice and rats1. The centella glycosides when injected into anaesthetised rats significantly lowered the blood pressure2. It was observed that alcoholic extract decreased the acetylcholine and histamine content of the whole brain homogenate of albino rats. Inhibition of the increase in acetylcholine in the brain in stressed rats was observed3.

Clinical Applications
Traditionally used for the decoction of the whole herb is used for treatment of colds, sunstroke, tonsillitis,urinary tract infection, hepatitis, jaundice, skin diseases, chronic rheumatism, amenorrhoea and dysentery and also a blood purifier. It is also used as a folk remedy for leprosy, lumps and syphilis, tuberculosis and for improving mental function1-2. Chinese medicine uses various parts of the plant. The leaves are used for leukorrhea and fevers that are toxic, while other types of fevers and boils are treated with gotu kola shoots. Gotu kola has been used for centuries as a brain tonic and used for longevity has become very popular in China. .
Traditional use of Gotu Kola in India and Indonesia included wound treatment. In the 1800s, it became part of Indian medicine practice and was used to treat many skin conditions including leprosy, varicose ulcers, and eczema, as well as fever, diarrhea, and absence of menses. In Africa peoples used for the treatment of leprosy (the asiaticoside content dissolves the waxy coating of the leprosy bacteria - allowing the immune system to destroy the bacteria), bronchitis, asthma, syphilis and wound healing· Can be used for improving memory, overcoming stress and fatigue.3 Increases intelligence quotient in mentally retarded children.Helps prevent Varicose Veins/Hemorrhoids Studies have also shown that gotu kola has positive effects on varicose veins and hemorrhoids.A 1992 review of all the gotu kola studies available concluded that gotu kola extract provides a dose-related improvement in venous insufficiency symptoms, reducing foot swelling, ankle edema, and fluid leakage from the veins.4 Helps heal Wounds / Burns / Scars/ Skin Inflammation Gotu kola has positive effects on various skin problems. Animal research has shown that tripenoid asiaticoside may help wounds heal quicker. Other studies showed that gotu
kola helped in healing surgical wounds of the ear, nose, and throat, and promoted healing of episiotomies, gangrene skin grafts, and some skin ulcers. In a French study done in 1966 it was found that it had a significant healing effect when used after episiotomy - a surgical cut of the vulva to prevent tearing during childbirth. The cut healed more rapidly than with standard treatment. Gotu kola was used in treatment of patients with second or third degree burns from boiling water or gas explosions if the burn is treated immediately. The extract can stop or reduce the shrinkage and swelling of the skin caused by infection and inhibited scar formation, increasing healing and reducing fibrosis. It has been used to prevent the development of keloid (bulging, enlarged) scars following surgery,studies suggest that gotu kola extracts may be useful in treating anal fissures,bladder ulcers, dermatitis, , perineal lesions,striae gravidarum Clinical trials also show that gotu kola's tripenoids, when purified, can lessen the ravages of scleroderma. In addition to decreased skin hardening, patients have noticed a lessening of joint pain and improved finger motility.. Treatment of liver and kidney problems It has been used for centuries in the treatment of liver and kidney problems, and has once again become popular as an alternative treatment for people suffering from hepatitis as well as alcoholic liver disease.
Research shows gotu kola extract also can be effective in other diseases, anti-spasmodic activity, hypothyroidism,venous hypertension,antidote to cholera,gastric catarrh urethritis,periodontal disease,reduce cellulite,liver cirrhosis,tumors,epilepsy,alopecia,psoriasis jaundice,anemia,diabetes,phlebitis,tonsillitis,insomnia.

 

Common Use of Gotu Kola:
Prevention of mental fatigue and enhanced concentration and memory. A balancing tonic that both increases energy and relaxes the body. Stimulates the central nervous system, aids circulation especially in the legs, and is a mild diuretic. Aids in many types of wound healing. Used for rheumatism, blood diseases, mental disorders, high blood pressure, congestive heart failure, sore throat, and hepatitis.
 Key Actions of Gotu kola products:anti-inflammatory,antitumor,antirheumatic,heals wounds,mild diuretic,peripheral vasodilator,sedative,tonic,ulcer protective,Promote longevity,Improve your memory,Stimulate brain cell vitality,Build neural and mental stamina,Increase your mental abilities,Avoid senility and dullness,Reduce stress and anxiety,Nurture tranquility,Claims Helps prevent Varicose Veins/Hemorrhoids,Helps heal Scars/Burns/Wounds,Reduces Skin Inflammation and Skin Wrinkles (smoother skin),Cellulite reduction,Increases Energy levels,Improves Memory and Circulation,Promotes restful Sleep,etc.
 Possible Benefits of Gotu Kola:
 Major use:Skin ailments
 Gotu kola increases mental acuity and boosts memory.
 Gotu kola help to Builds connective tissue.
 Promotes healthy blood vessels by strengthening veins and capillaries to improve circulation.
 Helpful for varicose veins.
 Reduces pain and swelling due to phlebitis.
 Works as nerve tonic to promote relaxation.
 Promotes healing after childbirth.
 Relieves congestion due to colds and upper respiratory infections.
 Gotu Kola Helps reduce fevers.
 Gotu Kola acts as a mild diuretic.
 
 Gotu Kola is the main Ayurvedic brain-mind tonic for children and adults.
 Gotu kola products used as good I.Q. and mental ability stimulator.
 Gotu Kola as General antibiotics with super wound healing and anti-inflammatory activities.
 Gotu Kola affects tissue development.
 Gotu kola treat Leprosy & skin disorders:
 gotu kola used as general Tonic:
 Gotu kola and Fertility - Research in the rnid-1990s suggests that asiaticocide and thankuniside may reduce fertility, a finding that contrasts with one of the herb's traditional uses -in India it is taken to improve fertility.
 Gotu kola help to lower blood sugar levels:
 Gotu Kola powder paste used on patches of eczema.
 Detox property of Gotu kola,Gotu Kola destroys toxic accumulations in the brain and nerves including residues of heavy metals and pharmaceutical and recreational drugs.
 Gotu Kola as Coffee Substitute
 Gotu Kola Treat Cancer:
 Gotu Kola is used to treat cancer and tumors.
 Gotu kola as Kidney/Liver tonic:
 Gotu kola is considered to be a nerve-tonic at low doses and a relaxant in higher doses; apparently at low doses it stimulates mental functions and at higer doses it produces sedativity. Another interesting property is its ability to stimulate wound healing.
 Autonomic changes: sedativity, anticonvulsant- and mild diuretic activity, peripheral vasodilation and an increases bloodflow.
 

  Some Traditional Uses: In India and Indonesia, used for lupus, leprosy, and wounds; in India and other parts of Asia, used for longevity and memory. Also used for fatigue, mental acuity, venous insufficiency, skin conditions such as scabies, psoriasis, and fungal infections, wounds, and much more. Also used in China.

  Current Medicinal Uses and Purposes: Boosts immune system; protects against stress; improved learning and memory; good for wounds, some chronic ulcers and lesions, and skin conditions, including psoriasis

  Areas of Further Research: Gotu kola may be helpful in the treatment of varicose veins, cancer, and chronic liver disorders. Antifertility and blood-pressure-lowering effects observed in mice.Centella asiatica has been subjected to quite extensive clinical investigations. Currently, clinical studies aimed at investigating the sedative, analgesic, antidepressive, antimicrobial, antiviral and immunomodulatory effects that have been demonstrated experimentally, are still lacking.

 

 

 

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